Ethical guidelines for conducting clinical trials have historically been based on a perceived therapeutic obligation to treat and benefit the patient-participants. The origins of this ethical framework can be traced to the Hippocratic oath originally written to guide doctors in caring for their patients, where the overriding moral obligation of doctors is strictly to do what is best for the individual patient, irrespective of other social considerations. In contrast, although medicine focuses on the health of the person, public health is (...) concerned with the health of the entire population, and thus, public health ethics is founded on the societal responsibility to protect and promote the health of the population as a whole. From a public health perspective, research ethics should be guided by giving due consideration to the risks and benefits to society in addition to the individual research participants. On the basis of a duty to protect the population as a whole, a fiduciary obligation to realise the social value of the research and the moral responsibility to distribute the benefits and burdens of research fairly across society, how a public health perspective on research ethics results in fundamental re-assessments of the proper course of action for two salient topical issues in research ethics is shown: stopping trials early for reasons of efficacy and the conduct of research on less expensive yet less effective interventions. (shrink)

With his usual conciseness and lucidity, Körner attempts to show what philosophy is by looking at what it does, i.e., by investigating its problems, its branches and its history. Körner begins by setting out classic problems ranging from the problem of class-existence to the problem of freedom, and follows this by an investigation of various methodologies. After this introductory material the bulk of the book ranges over the central problems of most branches of philosophy and concludes with a brief sketch (...) of the history of philosophy. Of special note is Körner's treatment of metaphysics to which he gives an entire section of almost seventy pages. Those familiar with Körner's other work will find it a concise summary of his notion of metaphysics as exhibition and/or replacement-analysis of categorial frameworks. Also of note is his refreshing treatment of philosophy of mind. He sees the problem of intentionality as the chief consideration for that branch of philosophy. Although he makes mention of the linguistic approach to philosophy of mind his main thrust is to set the problems in Brentano's terms and show how the mind-body problem and theories of truth are handled from that framework. There are some drawbacks in the book. First: given the length of his treatment of metaphysics one could wish that somewhere Körner in his explication of metaphysics had given some recognition to the realistic alternatives to his transcendental metaphysics. Second: one must wonder to whom the book is addressed. The conciseness of Körner's style allows him to range over an unbelievably large area, but in such a pithy manner that it seems almost unimaginable that the educated layman will be able to follow the presentations and arguments, particularly those interspersed with logical notation. For example, how much value is there in condensing the logic of truth-functions, quantification and axiomatization into less than ten pages? For those in the field it is repetitive, for those not, it must be nearly unintelligible. One feels Körner really wanted to write a defense of metaphysics. This may have been a more efficacious project eliminating the need to write first for one audience then for another. The book is concise, lucid, and illuminating.--R. F. D. (shrink)

In this monograph R. W. Beardsmore presents a lucid and readable presentation of what he takes moral reasoning to be and what he expects moral reasoning to accomplish. It is another in the long list of works which attempt to apply later-Wittgensteinian insights to the problems of ethics. The common moves run this way: Wittgenstein insists that to say that something is justified, or to say there are justifiable reasons for some position implies some fundamental agreement in our language game. (...) Moral argumentation can only take place within the context of a shared ethical language game. This moral viewpoint invests, what appear to be facts with value. According to Beardsmore the importance of shared moral viewpoints is missed by R. M. Hare with his dichotomizing of fact and value and his insistence on a decision of principle. Beardsmore also attacks the position of Phillipa Foot whom he sees on the opposite side of the issue from Hare. He sees Foot as insisting on the necessary dependence of values upon facts, which leads to her inability to account for changing moral viewpoints. Beardsmore tries to show that these views of Foot and Hare agree at least on one point, that there must be one specific way to give reasons for moral positions and hence solve moral disputes. Beardsmore has made a significant contribution by offering an illuminating application of Wittgenstein's insights to the problems of ethical theory. If they did nothing more, these insight's would be important in so far as they help to unlock the hold that the fact-value dichotomy has imposed on ethical theory for so long.--R. F. D. (shrink)

All logic instruments and tools in possession of, and used by researchers are generally considered as the results of bivalent logic. A common error to people interested in science is that, usually, they don’t known with certainty which things are true and which are false. But they are sure that things are true or false. No ways in the middle. The fuzzy principle asserts that this is completely a question of measure. Fuzziness is the opposite concept to bivalency, while fuzzy (...) quality means polyvalency. Fuzzy logic is able to manage uncertain knowledge and, more precisely, to manage those rules difficult to formalize. In many cases, such rules haven’t got, or cannot have, the necessary precision, required for a whole formalization. (shrink)

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

Stakeholder theory is widely recognized as a management theory, yet very little research has considered its implications for individual managerial decision-making. In the two studies reported here, we used stakeholder theory to examine managerial decisions about balancing stakeholder interests. Results of Study 1 suggest that indivisible resources and unequal levels of stakeholder saliency constrain managers’ efforts to balance stakeholder interests. Resource divisibility also influenced whether managers used a within-decision or an across-decision approach to balance stakeholder interests. In Study 2 we (...) examined instrumental and normative implications of these two approaches. We conclude by considering the contributions of this research. (shrink)

Adaptive management is commonly identified as a way to address situations where ecological and social uncertainty exists. Two discourses are common: a focus on experimentation, and a focus on collaboration. The roles of experimental and collaborative adaptive management in contemporary practice are reviewed to identify tools for bridging the discourses. Examples include broadening the scope of contributions during the buy-in and goal-setting stages, using conceptual models and decision support tools to include stakeholders in model development, experimentation using indicators of concern (...) to stakeholders, an experimental focus that reflects the level of statistical confidence required by management, and the engagement of stakeholders in data interpretation so that those affected by management outcomes can learn and adapt accordingly. In this context, a framework of questions that managers can use to reflect on both ecological and social uncertainties as they relate to individual management contexts is proposed. (shrink)

I would refer to the introductory paragraphs of J. Diggle's ‘Notes on Ovid's Tristia, Books I-II’ , 401–19). His list of modern editions does not include F. Della Corte, I Tristia , which I too have not seen. For Book IV we have an edition by T. J. de Jonge.

Although modern texts of Propertius have generally inclined to conservatism, there remains a number of cases where editors have chosen, in Housman's phrase, timidly to alter what they might without rashness have defended; or where the arguments so far advanced in favour of the best attested reading leave room for supplement. Thus: I. 6. 25 f. me sine, quem semper uoluit fortuna iacere, hanc animam extremae reddere nequitiae. extrema … nequitia Fonteine.

Although modern texts of Propertius have generally inclined to conservatism, there remains a number of cases where editors have chosen, in Housman's phrase, timidly to alter what they might without rashness have defended; or where the arguments so far advanced in favour of the best attested reading leave room for supplement. Thus: I. 6. 25 f. me sine, quem semper uoluit fortuna iacere, hanc animam extremae reddere nequitiae. extrema … nequitia Fonteine.

The DAMA project is an observatory for rare processes and it is operative deep underground at the Gran Sasso National Laboratory of the I.N.F.N. In particular, the DAMA/LIBRA (Large sodium Iodide Bulk for RAre processes) set-up consists of highly radiopure NaI(Tl) detectors for a total sensitive exposed mass of ≃250 kg. Recent results, obtained by this set-up by exploiting the model independent annual modulation signature of Dark Matter (DM) particles, have confirmed and improved those obtained by the former DAMA/NaI experiment. (...) A model independent evidence for the presence of Dark Matter particles in the galactic halo is cumulatively obtained at 8.2 σ C.L. No systematics or side reactions able to account for the measured modulation amplitude and to contemporaneously satisfy all the many specific requirements of the signature have been found or suggested by anyone over more than a decade. An example of one of the many possible model dependent corollary quests for the candidate particles and for the related astrophysical, nuclear and particle physics scenarios is presented considering the whole cumulative exposure. Future perspectives are shortly addressed. (shrink)

R. Renehan's ingenious solutions to the problems of Symphosius 42. 1 and Anth. Lat. 207 in this journal, 471 f.) are much to be welcomed. On the other hand, I do not think that his defence of the manuscript reading in Anth. Lat. 24. 3 marcent post rorem violae, rosa perdit odorem holds water. Taking rorem as = rorem marinum he explains that ‘the poet is not presenting us with a piece of botanical information about the relative seasons of the (...) violet and rosemary; he means rather that all flowers wither and fade’. Actually, however, the poet on this showing does present information; and whether the information is botanically correct or not, that is an odd way to make his point. Stranger still is his choice of rosemary out of all the fading flowers of field and garden. It was bound to be I misunderstood. As Renehan indicates, ros = ros marinus is supported only by Virg. Georg. 2. 212–13, where the identity has been doubted, and Plin. HN 24. 100, where ex rore supra dicto refers back to ros marinum in 99. Renehan may well be the first reader not to take rorem as dew. And an evergeen shrub makes a singularly unfortunate illustration of floral decay, even though the shrub does produce a flower. Pliny classes it with herbs. (shrink)

R. Renehan's ingenious solutions to the problems of Symphosius 42. 1 and Anth. Lat. 207 in this journal , 471 f.) are much to be welcomed. On the other hand, I do not think that his defence of the manuscript reading in Anth. Lat. 24. 3 marcent post rorem violae, rosa perdit odorem holds water. Taking rorem as = rorem marinum he explains that ‘the poet is not presenting us with a piece of botanical information about the relative seasons of (...) the violet and rosemary; he means rather that all flowers wither and fade’. Actually, however, the poet on this showing does present information; and whether the information is botanically correct or not , that is an odd way to make his point. Stranger still is his choice of rosemary out of all the fading flowers of field and garden. It was bound to be I misunderstood. As Renehan indicates, ros = ros marinus is supported only by Virg. Georg. 2. 212–13, where the identity has been doubted, and Plin. HN 24. 100, where ex rore supra dicto refers back to ros marinum in 99. Renehan may well be the first reader not to take rorem as dew. And an evergeen shrub makes a singularly unfortunate illustration of floral decay, even though the shrub does produce a flower. Pliny classes it with herbs. (shrink)

Introduction While quizzing during informed consent for research to ensure understanding has become commonplace, it is unclear whether the quizzing itself is problematic for potential participants. In this study, we address this issue in a multinational HIV prevention research trial enrolling injection drug users in China and Thailand. Methods Enrolment procedures included an informed consent comprehension quiz. An informed consent survey followed. Results 525 participants completed the informed consent survey (Heng County, China=255, Xinjiang, China=229, Chiang Mai, Thailand=41). Mean age was (...) 33 and mean educational level was 8 yrs. While quizzing was felt to be a good way to determine if a person understands the nature of clinical trial participation (97%) and participants did not generally find the quiz to be problematic, minorities of respondents felt pressured (6%); anxious (5%); bored (5%); minded (5%); and did not find the questions easy (13%). In multivariate analysis, lower educational level was associated with not minding the quizzing (6–10 yrs vs 0–5 yrs: OR=0.27, p=0.03; more than 11 yrs vs 0–5 yrs: OR=0.18, p=0.03). There were also site differences (Heng County vs Xinjiang) in feeling anxious (OR=0.07; p=<0.01), not minding (OR=0.26; p=0.03), being bored (OR=0.25; p=0.01) and not finding the questions easy (OR=0.10; p=<0.01). Conclusions Quizzing during the informed consent process can be problematic for a minority of participants. These problems may be associated with the setting in which research takes place and educational level. Further research is needed to develop, test and implement alternative methods of ensuring comprehension of informed consent. Trial Registration clinicaltrials.gov number NCT00270257. (shrink)